KLOW (GHK-Cu + TB-500 + BPC-157 + KPV)

€200,00 EUR

In stock

KLOW is a four-peptide complex studied in the field of tissue regeneration, skin condition, and inflammation regulation. To the GLOW formula (the copper peptide GHK-Cu, BPC-157, and TB-500), it adds KPV, a tripeptide derived from the α-MSH hormone that is being researched for its anti-inflammatory action. Each component acts on a different phase of repair: collagen synthesis, blood vessel formation, cell migration, and inflammation control. At PurePeptides, KLOW is supplied with a certificate of analysis for each batch.

Pen: 80 mg of peptides in 3 ml of solution (GHK-Cu 50 mg, BPC-157 10 mg, TB-500 10 mg, and KPV 10 mg) and 300 clicks.
Each click (0.01 ml) contains 0.167 mg of GHK-Cu and 0.033 mg of BPC-157, TB-500, and KPV.

Storage: in the refrigerator and protected from light.

KLOW combines four peptides that have been studied separately:

GHK-Cu (50 mg): a complex of the tripeptide Gly-His-Lys with copper, naturally present in human plasma.
BPC-157 (10 mg): a synthetic 15-amino acid peptide whose sequence is derived from a protein in gastric juice.
TB-500 (10 mg): a synthetic peptide based on the active region of thymosin beta-4.
KPV (10 mg): the tripeptide Lys-Pro-Val, the C-terminal end of the alpha-melanocyte-stimulating hormone (α-MSH).

GHK-Cu is the major component and provides the line of study on the extracellular matrix and the skin. BPC-157 and TB-500 provide tissue repair, and KPV provides inflammation regulation. Together, the formula covers the main phases of tissue repair: inflammation, blood vessel formation, cell migration, and remodeling.

KPV (Lys-Pro-Val) corresponds to the last three amino acids of α-MSH, the region responsible for much of its anti-inflammatory activity. Unlike the full hormone, KPV is not associated with skin pigmentation.

Its best-described mechanism is intracellular: it enters cells via the peptide transporter PepT1 and, once inside, reduces NF-κB pathway activation and the production of proinflammatory cytokines. In cellular and animal models, it has been studied in relation to:

intestinal inflammation in colitis models (Dalmasso et al., Gastroenterology, 2008);
skin inflammation and wound healing;
the antimicrobial activity described for the C-terminal fragments of α-MSH.

Its molecular formula is C16H30N4O4 and its molecular weight is 342.4 g/mol.

The other three components of KLOW have their own lines of research:

GHK-Cu: in fibroblasts, it stimulates the synthesis of collagen, elastin, and glycosaminoglycans, and regulates the enzymes that remodel the extracellular matrix. This is why copper peptides are also a common ingredient in cosmetics.
BPC-157: studied primarily in rodents, it is associated with the formation of new blood vessels through VEGF and nitric oxide, as well as the repair of tendons, ligaments, and digestive mucosa.
TB-500: replicates the region of thymosin beta-4 that binds to actin. Tβ4 has been studied for its role in cell migration and in the repair of wounds in the skin, cornea, and heart.

Each peptide has been researched separately. The interest in combining them lies in the fact that their mechanisms complement each other without overlapping.

KLOW is supplied in a pen, a ready-to-use format that does not require the reconstitution of a lyophilisate. It contains 80 mg of peptides in 3 ml of solution, with the following concentrations:

GHK-Cu: 50 mg (16.7 mg/ml);
BPC-157: 10 mg (3.3 mg/ml);
TB-500: 10 mg (3.3 mg/ml);
KPV: 10 mg (3.3 mg/ml).

The scale has 300 clicks of 0.01 ml. Due to the copper in the GHK-Cu, the solution has a characteristic blue color. The pen should be stored in a refrigerator, between 2 and 8 °C, without freezing and protected from direct light.

HPLC Analysis
(Purity >98%)

Express shipping with cold chain

24 months shelf life

Fast shipping throughout the EU

FAQ

Four peptides, 80 mg total in 3 ml of solution:

GHK-Cu: 50 mg;
BPC-157: 10 mg;
TB-500: 10 mg;
KPV: 10 mg.

KLOW includes the three GLOW peptides (GHK-Cu, BPC-157, and TB-500) and adds KPV. With it, the formula incorporates a line of study focused on the regulation of inflammation.

It is the tripeptide Lys-Pro-Val, the C-terminal fragment of the α-MSH hormone. It is being studied for its anti-inflammatory action: it enters cells via the PepT1 transporter and reduces activation of the NF-κB pathway.

Each click corresponds to 0.01 ml of solution and contains:

GHK-Cu: 0.167 mg (167 mcg);
BPC-157: 0.033 mg (33 mcg);
TB-500: 0.033 mg (33 mcg);
KPV: 0.033 mg (33 mcg).

In total, 0.267 mg of peptides per click.

In the refrigerator, between 2 and 8 °C, do not freeze and protect from direct light. A cold chain is maintained during shipping. The blue color of the solution is due to the copper in the GHK-Cu and is normal.

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The product is intended exclusively for scientific research and laboratory use. It is not a medication or food product and is not intended for use in humans or animals for medical purposes.