MOTS-C

€200,00 EUR

In stock

MOTS-c is a mitochondria-derived peptide: its sequence is encoded in the mitochondrial DNA, within the MT-RNR1 gene, and not in the cell nucleus. It belongs to a relatively recently described family of signaling molecules, the mitochondria-derived peptides. It is being studied for its role in the regulation of energy metabolism, insulin sensitivity, and skeletal muscle function. At PurePeptides, MOTS-c is available in a pen and spray, with a purity greater than 98% and a certificate of analysis for each batch.

Pen: 30 mg of MOTS-c in 3 ml of solution (10 mg/ml) and 300 clicks; each click corresponds to 0.1 mg (0.01 ml).
Spray: 55 sprays per container; each spray contains 200 mcg (0.2 mg) of MOTS-c, 11 mg total.

Storage: refrigerated and protected from light

Spray:200 μg per actuation

Syringe pen:30 mg / 3 ml
300 units (actuations)
1 unit (1 actuation) ≈ 0.1 mg

The best-described mechanism of MOTS-c focuses on skeletal muscle:

it inhibits the folate cycle and de novo purine synthesis;
this causes the accumulation of AICAR, a metabolic intermediate;
AICAR activates AMPK, the enzyme that acts as the cell's energy sensor and regulates glucose uptake and fat oxidation.

In situations of metabolic stress, MOTS-c translocates to the cell nucleus. There, it interacts with the NRF2 factor and regulates the expression of antioxidant response genes (Kim et al., Cell Metabolism, 2018). It is a direct example of communication between the mitochondria and the nucleus.

In laboratory models, MOTS-C is investigated across several avenues of research:

AMPK activation, a key enzyme regulating cellular energy metabolism;
Influence on glucose metabolism and insulin sensitivity;
Neuroprotective potential;
Involvement in skeletal muscle mitochondrial function;
Modulation of stress response via heat shock proteins (HSP), GSK-3β, and inhibition of the JNK signaling pathway.

Research topics include prediabetes, insulin resistance, metabolic syndrome, and age-associated metabolic decline. These findings originate from experimental models and do not constitute claims regarding effects in humans.

MOTS-c is available in two ready-to-use formats that do not require reconstituting a lyophilizate:

Pen: 30 mg of MOTS-c in 3 ml of solution (10 mg/ml). The dial has 300 clicks; each click corresponds to 0.01 ml, containing 0.1 mg of MOTS-c.
Spray: each container provides 55 sprays of 200 mcg (0.2 mg) of MOTS-c, 11 mg in total.

Both formats should be stored in a refrigerator, between 2 and 8 °C, and protected from direct light.

HPLC Analysis
(Purity >98%)

Express shipping with cold chain

24 months shelf life

Fast shipping throughout the EU

FAQ

It is a 16-amino acid peptide encoded in mitochondrial DNA, within the MT-RNR1 gene. Its name comes from the English "mitochondrial open reading frame of the 12S rRNA type-c." It is being studied for its role in energy metabolism and insulin sensitivity.

At its origin. Most peptides are encoded in the cell nucleus DNA, while MOTS-c comes from the mitochondrial genome. This is why it is part of a small group of molecules, the mitochondria-derived peptides.

Because physical activity increases its levels in skeletal muscle and in the blood, and because it activates AMPK, the same enzyme that is activated during exercise. For this reason, it is often described in scientific literature as an exercise mimetic.

Pen: 0.1 mg per click (0.01 ml), with 300 clicks and 30 mg total.
Spray: 200 mcg (0.2 mg) per spray, with 55 sprays and 11 mg total.

In the refrigerator, between 2 and 8 °C, and protected from direct light. A cold chain is maintained during shipping.

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The product is intended exclusively for scientific research and laboratory use. It is not a medication or food product and is not intended for use in humans or animals for medical purposes.