BPC-157 + TB-500 (Wolverine stack)

€150,00 EUR

In stock

BPC-157 + TB-500 (Wolverine stack) is a combination of two peptides extensively studied in the field of tissue regeneration. It brings together in a single formula BPC-157, a pentadecapeptide studied in relation to angiogenesis and the repair of tendons, ligaments, and digestive mucosa, and TB-500, a peptide derived from thymosin beta-4 that is involved in cell migration and actin dynamics. Their mechanisms do not overlap, but rather complement each other, which is why the combination sparks interest in studies on healing, blood vessel formation, and inflammation regulation. At PurePeptides, each batch is supplied with its certificate of analysis.

The complex combines two distinct classes of molecules that, in preclinical models of injury, act at different stages of tissue repair.

BPC-157 is a synthetic 15-amino acid peptide (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val). Its sequence is derived from a protein found in human gastric juice called BPC (body protection compound). Its CAS number is 137525-51-0 and its molecular weight is approximately 1419 g/mol.

TB-500 is a synthetic peptide based on thymosin beta-4 (Tβ4), a 43-amino acid protein found in almost all cells of the body. It replicates its active region, the one that binds to actin.

Each peptide has been investigated separately. The interest in combining them is based on the fact that their mechanisms are complementary: BPC-157 acts primarily at the vascular and connective tissue level, and TB-500 on the migration of cells to the damaged area.

In experimental models, mainly in rodents, BPC-157 has been studied in the following areas:

increase of angiogenic factors, such as VEGF, and the expression of its receptor VEGFR2;
participation in nitric oxide (NO)-dependent vascular responses;
modulation of inflammatory mediators, such as the NF-κB pathway and pro-inflammatory cytokines;
repair of the digestive tract mucosa;
healing of tendons and ligaments, with increased fibroblast proliferation and migration.

Much of this work comes from Predrag Sikirić's group at the University of Zagreb. Among the most frequently cited studies are those by Chang et al. (Journal of Applied Physiology, 2011), on tendon fibroblasts, and Hsieh et al. (Journal of Molecular Medicine, 2017), on VEGFR2 activation.

Most of the published research has been conducted with full-length thymosin beta-4, whose active region is replicated by TB-500. In cellular and animal models, it has been studied in relation to:

actin regulation: Tβ4 is the primary protein that sequesters monomeric actin in the cell, which influences its shape and movement;
cell migration to the damaged area;
angiogenesis;
skin, corneal, and cardiac tissue wound repair.

Reference works include Malinda et al. (Journal of Investigative Dermatology, 1999), on skin healing, and Bock-Marquette et al. (Nature, 2004), on cardiac repair in mice.

The format and content of each presentation are indicated on the product datasheet. Lyophilized presentations are reconstituted with a solvent before use. The lyophilizate is stable during storage. Once opened or reconstituted, the product must be kept refrigerated at no more than 5 °C and protected from light.

HPLC Analysis
(Purity >98%)

Express shipping with cold chain

24 months shelf life

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FAQ

Two peptides: BPC-157, a synthetic pentadecapeptide derived from a gastric juice protein, and TB-500, a synthetic peptide based on the active region of thymosin beta-4.

Because they act through different, complementary pathways:

BPC-157: angiogenesis (VEGF, nitric oxide) and repair of tendons, ligaments, and digestive mucosa;
TB-500: regulation of actin and cell migration to the damaged area.

Thymosin beta-4 (Tβ4) is a natural 43-amino acid protein. TB-500 is a shorter synthetic peptide that reproduces its active region, which binds to actin. Most published studies have been conducted with full-length Tβ4.

The lyophilizate is stable during storage. Once opened or reconstituted, store in a refrigerator at no more than 5 °C and protect from light.

The product page specifies the format and content of each presentation. If you need more information about the batch, our team will confirm it for you before you place your order.

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The product is intended exclusively for scientific research and laboratory use. It is not a medication or food product and is not intended for use in humans or animals for medical purposes.