NAD+

€60,00 EUR

In stock

NAD+ (nicotinamide adenine dinucleotide) is a key coenzyme in cellular metabolism: it participates in oxidation-reduction reactions, energy production in the mitochondria, and the activity of enzymes such as sirtuins. Due to its role in energy metabolism and aging biology, it is one of the most studied molecules in current research. At PurePeptides, NAD+ is available in a pen and spray, with a purity of 99.1% or higher and a certificate of analysis for each batch.

Pen: 900 mg of NAD+ in 3 ml of solution (300 mg/ml) and 300 clicks; each click corresponds to 3 mg (0.01 ml).
Spray: 55 sprays per container; each spray contains 5 mg of NAD+ (275 mg total).

Storage: in the refrigerator and protected from light.

Spray:5 mg per puff

Pre-filled pen:900 mg / 3 ml (300 mg/ml)
300 units (puffs)
1 unit (1 puff) ≈ 3 mg

In addition to participating in oxidation-reduction reactions, NAD+ is the cosubstrate for several groups of enzymes that consume it as they act:

Sirtuins (SIRT1–SIRT7): deacetylases that regulate gene expression, metabolism, and the stress response. Their activity depends directly on NAD+ availability.
PARPs (poly-ADP-ribose polymerases): enzymes involved in DNA repair.
CD38: an enzyme that degrades NAD+ and whose activity increases with age in animal models.

In the mitochondria, NADH donates its electrons to complex I of the respiratory chain, an essential step for ATP production. For this reason, the balance between NAD+ and NADH is considered an indicator of the cell's energy status.

Research on NAD+ focuses on several lines:

the decline of NAD+ levels with age, observed in animal models and in some human tissues;
the relationship between that decline and mitochondrial function;
the role of sirtuins in metabolism and cellular aging;
strategies to restore NAD+ levels, using the molecule itself or its precursors, such as NMN or NR.

Key reference works include Gomes et al. (Cell, 2013), which linked the decline of NAD+ to impaired communication between the nucleus and the mitochondria in aged mice. Also, the study by Camacho-Pereira et al. (Cell Metabolism, 2016), which identified CD38 as one of the main causes of that decline, and Verdin’s review (Science, 2015) on NAD+ in aging, metabolism, and neurodegeneration.

NAD+ is available in two ready-to-use formats that do not require reconstituting a lyophilizate:

Pen: contains 900 mg of NAD+ in 3 ml of solution, which is a concentration of 300 mg/ml. The dial has 300 clicks; each click corresponds to 0.01 ml, containing 3 mg of NAD+.
Spray: each container allows for 55 sprays of 5 mg of NAD+, 275 mg in total.

In solution, NAD+ is sensitive to temperature and light, so both formats must be stored in the refrigerator, between 2 and 8 °C, and protected from direct light.

HPLC Analysis
(Purity >98%)

Express shipping with cold chain

24 months shelf life

Fast shipping throughout the EU

FAQ

It is nicotinamide adenine dinucleotide, a coenzyme present in all cells. It participates in oxidation-reduction reactions, in energy production in the mitochondria, and in the activity of sirtuins.

In the 900 mg / 3 ml presentation, one pump contains approximately 3 mg of NAD+

NMN (nicotinamide mononucleotide) is a precursor: the cell converts it into NAD+ in a single step. NAD+ is the final coenzyme, the molecule that participates directly in reactions. Other precursors include NR (nicotinamide riboside), nicotinamide, and nicotinic acid.

Pen: 3 mg per click (0.01 ml), with 300 clicks and 900 mg in total.
Spray: 5 mg per spray, with 55 sprays and 275 mg in total.

In the refrigerator, between 2 and 8 °C, and protected from direct light. A cold chain is maintained during shipping.

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The product is intended exclusively for scientific research and laboratory use. It is not a medication or food product and is not intended for use in humans or animals for medical purposes.