5-amino-1MQ (NNMT inhibitor)

€200,00 EUR

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5-amino-1MQ (5-amino-1-methylquinolinium) is a low-molecular-weight compound studied as a selective inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). This enzyme is linked to the regulation of cellular metabolism and NAD+ levels, which is why its inhibitors are of great interest in metabolic research. At PurePeptides, 5-amino-1MQ is offered exclusively for scientific research, with a purity greater than 99% confirmed by a certificate of analysis.

Each pen contains 100 mg in 3 ml of solution and allows for 300 clicks; each click corresponds to 0.333 mg (0.01 ml).

Storage: the pen should be stored at room temperature.

The chemical name of the compound is 5-amino-1-methylquinolin-1-ium iodide, and it is also known as 5-amino-1MQ, NNMTi, or NNMT inhibitor. Its CAS number is 42464-96-0 (iodide salt), its molecular formula is C10H11IN2, and its molecular weight is 286.11 g/mol. It is supplied in a pen format, with a purity greater than 99%, and is stored at room temperature.

5-amino-1MQ is not a peptide, but a small molecule derived from quinoline. Its target is NNMT, a cytosolic enzyme that methylates nicotinamide (a form of vitamin B3) using S-adenosylmethionine (SAM) as a methyl donor and produces 1-methylnicotinamide (1-MNA). By removing nicotinamide from the NAD+ salvage pathway, NNMT influences both the cellular NAD+ pool and the methylation cycle. Thanks to this targeted action, 5-amino-1MQ is a useful tool for studying energy metabolism.

In laboratory models, 5-amino-1MQ is studied along the following lines:

inhibition of the NNMT enzyme and its selectivity against other methyltransferases;
the role of NNMT in energy metabolism and in diet-induced obesity models;
the effect on nicotinamide metabolism and intracellular levels of NAD+ and SAM;
skeletal muscle regeneration in aging models.

The reference works are those of Neelakantan et al. in Biochemical Pharmacology. The 2018 study characterizes the compound in adipocytes and in mice with diet-induced obesity, and the 2019 study focuses on muscle stem cells of aged mice. Interest in NNMT as a metabolic target is further supported by the study by Kraus et al. (Nature, 2014) on the silencing of this enzyme.

These data come from in vitro and animal studies and do not constitute a claim regarding effects in humans. 5-amino-1MQ is not approved as a medication or as a dietary supplement.

HPLC Analysis
(Purity >98%)

Express shipping with cold chain

24 months shelf life

Fast shipping throughout the EU

FAQ

No. It is a low-molecular-weight inhibitor of the NNMT enzyme, not an amino acid chain.

Due to the role of NNMT in energy metabolism, nicotinamide metabolism, and NAD+ levels.

In pen format, at room temperature.

Greater than 99%, according to the certificate of analysis for each batch.

Yes, we ship to Spain and the rest of the countries in the European Union.

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The product is intended exclusively for scientific research and laboratory use. It is not a medication or food product and is not intended for use in humans or animals for medical purposes.